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Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. Gene therapy–dependent modulation of atrial electrophysiology may provide a more specific alternative to pharmacological and ablative treatment strategies. We hypothesized that genetic inactivation of atrial repolarizing ether-a-go-go–related gene (ERG) K + currents using a dominant-negative mutant would provide rhythm...
Two-pore-domain potassium (K 2P ) channels mediate K + background currents that stabilize the resting membrane potential and contribute to repolarization of action potentials in excitable cells. The functional significance of K 2P currents in cardiac electrophysiology remains poorly understood. Danio rerio (zebrafish) may be utilized to elucidate the role of cardiac K 2P...
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