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Through an unusual differentiation process, human trophoblast progenitors (cytotrophoblasts) give rise to tumor-like cells that invade the uterus. By an unknown mechanism, invasive cytotrophoblasts exhibit permanent cell cycle withdrawal. Here, we report molecular cytogenetic data showing that ∼20 to 60% of these interphase cells had acquired aneusomies involving chromosomes X, Y, or 16. The incidence...
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