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Adjuvant trastuzumab therapy improves survival of human epidermal growth factor receptor 2 (HER2)–positive women with early breast cancer (EBC). A careful monitoring of cardiac function is needed due to potential trastuzumab cardiotoxicity (Tcardiotox). To date, the incidence, timing, and phenotype of patients with Tcardiotox in clinical practice are not well known.A total of 499 consecutive HER2-positive...
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