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There are conflicting data on the role of a patent foramen ovale (PFO) in the pathogenesis of cryptogenic stroke. The aim of this study was to evaluate the incidence of cerebrovascular events associated with PFO in a large population of patients during mid-term follow-up.We prospectively investigated 446 consecutive patients (58% female, age 50±14years) in whom PFO was detected by contrast echocardiography...
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