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The RAI gene is also known as iASPP and PPP1R13L. Recent investigations have shown that the region encompassing RAI is important for the development of cancer in young and middle-aged persons. It has been speculated that the RAI product induces apoptosis by blocking NF-κB or inhibits apoptosis by blocking p53. Either way the gene could influence the survival of precancerous lesions. Here we report...
Homozygous carriers of a haplotype consisting of ERCC1 Asn118Asn A , ASE-1 G-21A G , RAI IVS1 A4364G A are at increased risk of lung cancer especially among women.Here, we analyse for gene-environment interactions with the predefined haplotype in a case cohort study including 428 lung cancer cases and a comparison group of 800 persons, all from the prospective Diet, Cancer...
Low DNA-repair capacity has been associated with increased risk of several types of cancer. mRNA levels of the nucleotide excision repair genes ERCC1 and XPD have been shown to correlate with the DNA-repair capacity. Likewise, mRNA levels of several DNA-repair genes including ERCC1 have been shown to be lower in lymphocytes from patients with lung cancer and head and neck cancer compared with healthy...
Earlier studies have indicated that sucrose increases 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)-induced aberrant crypt foci in the colon. In this study, we investigated the role of sucrose in IQ-induced genotoxicity of the colon mucosa and liver. Big Blue rats were fed with IQ (20ppm in feed) and/or sucrose (3.45 or 6.85wt.% in feed) for 3 weeks. IQ increased DNA strand breaks in the colon, whereas...
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