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Background
Studies of human patients have shown that most anti‐RBC alloantibodies are IgG1 or IgG3 subclasses, although it is unclear why transfused RBCs preferentially drive these subclasses over others. Though mouse models allow for the mechanistic exploration of class‐switching, previous studies of RBC alloimmunization in mice have focused more on the total IgG response than the relative distribution,...
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