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New asterosaponins archasterosides A (1), B (2), and the known regularoside A (3) were isolated from the Vietnamese starfish Archaster typicus and structurally elucidated by extensive NMR techniques and chemical transformations. Compounds 1–3 showed moderate cytotoxic activities against HeLa and mouse JB6 P + Cl41 cell lines. The most active, 2, induced basal AP-1- and p53-, but not NF-κB-transcriptional...
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