Search results for: Sophie Jaillard

Items from 1 to 13 out of 13 results

article

TNF regulates sialyl-Lewisx and 6-sulfo-sialyl-Lewisx expression in human lung through up-regulation of ST3GAL4 transcript isoform BX

Florent Colomb, Marie-Ange Krzewinski-Recchi, Fala El Machhour, Eric Mensier, more

Biochimie > 2012 > 94 > 9 > 2045-2053

Bronchial mucins from severely infected patients suffering from lung diseases such as chronic bronchitis or cystic fibrosis exhibit increased amounts of sialyl-Lewis ^x (NeuAcα2-3Galβ1-4[Fucα1-3]GlcNAc-R, sLe ^x ) glycan structures. In cystic fibrosis, sLe ^x and its sulfated form 6-sulfo-sialyl-Lewis ^x (NeuAcα2-3Galβ1-4[Fucα1-3](HO ₃ S-6)GlcNAc-R, 6-sulfo-sLe...

article

Xenobiotic metabolism and disposition in human lung: Transcript profiling in non-tumoral and tumoral tissues

Julie Leclerc, Elisabeth Courcot-Ngoubo Ngangue, Christelle Cauffiez, Delphine Allorge, more

Biochimie > 2011 > 93 > 6 > 1012-1027

The lung is directly exposed to a wide variety of inhaled toxicants and carcinogens. In order to improve our knowledge of the cellular processing of these compounds in the respiratory tract, we investigated the mRNA expression level of 380 genes encoding xenobiotic-metabolizing enzymes (XME), transporters, nuclear receptors and transcription factors, in pulmonary parenchyma (PP), bronchial mucosa...

article

Profiling gene expression of whole cytochrome P450 superfamily in human bronchial and peripheral lung tissues: Differential expression in non-small cell lung cancers

Julie Leclerc, Gilles Tournel, Elisabeth Courcot-Ngoubo Ngangue, Nicolas Pottier, more

Biochimie > 2010 > 92 > 3 > 292-306

Susceptibility to lung diseases, such as lung cancer and chronic obstructive pulmonary disease, is largely influenced by the metabolic capacity of lung tissues. This capacity is partly determined by the expression profile of the cytochromes P450 (CYPs), a superfamily of enzymes that have relevant catalytic properties toward exogenous and endogenous compounds. Using quantitative real-time RT-PCR, we...

article

Effects of Phosphodiesterase 5 Inhibitor on Pulmonary Vascular Reactivity in the Fetal Lamb

Sophie Jaillard, Benoît Larrue, Philippe Deruelle, Anne Delelis, more

The Annals of Thoracic Surgery > 2006 > 81 > 3 > 935-942

Nitric oxide released by pulmonary vascular endothelium is a potent vasodilator related to increased cyclic guanosine monophosphate (cGMP) content. Hydrolysis of cGMP is achieved predominately by cGMP-specific phosphodiesterases. Sildenafil is a selective phosphodiesterase-5 (PDE5) inhibitor. The purpose of the study is to assess the effects of sildenafil on pulmonary vascular circulation during the...

article

Consequences of Delayed Surgical Closure of Patent Ductus Arteriosus in Very Premature Infants

Sophie Jaillard, Benoît Larrue, Thameur Rakza, Eric Magnenant, more

The Annals of Thoracic Surgery > 2006 > 81 > 1 > 231-234

Surgical closure of ductus arteriosus is commonly indicated in premature newborns. The aim of this study was to assess short-term and mid-term effects of delayed surgical closure of the ductus arteriosus on respiratory and digestive outcome in extremely preterm infants. We retrospectively studied 58 infants less than 28 weeks gestational age who underwent surgical closure of ductus arteriosus between...

article

Influence of sympathetic tone on heart rate during vagal stimulation and nitroprusside induced hypotension in ovine fetus

Théophile Gaillot, Alain Beuchée, Sophie Jaillard, Laurent Storme, more

Autonomic Neuroscience: Basic and Clinical > 2005 > 123 > 1-2 > 19-25

To characterize effects of sympathetic tone on fetal heart rate (FHR) reflex responses and FHR variability in late gestation.Changes in FHR and autonomic tones were studied (i) after electrical vagal stimulation and (ii) during nitroprusside-induced hypotension, in seven late gestation ovine fetus in control condition (ctrl), after dobutamine (β1-activation) and atenolol (β1-blockade). Results are...

article

Preoperative ECMO in Transposition of the Great Arteries With Persistent Pulmonary Hypertension

Sophie Jaillard, Emre Belli, Thameur Rakza, Benoit Larrue, more

The Annals of Thoracic Surgery > 2005 > 79 > 6 > 2155-2158

Persistent fetal circulation in transposition of the great arteries results in severe persistent pulmonary hypertension, which increases the risk of early mortality. We report the case of a newborn with transposition of the great arteries and intact ventricular septum associated with pulmonary hypertension. After the failure of immediate balloon atrial septostomy and supportive therapy including inhaled...

article

Pulmonary vascular effects of sildenafil during the development of chronic pulmonary hypertension in the ovine fetus

Philippe Deruelle, Benoit Larrue, Mike Lorthioir, Ghazwan Butrous, more

American Journal of Obstetrics and Gynecology > 2004 > 191 > 6 Supplement > S119

article

Effects of phosphodiesterase 5 inhibitor on pulmonary vascular reactivity in the fetal lamb

Philippe Deruelle, Benoit Larrue, Thameur Rakzah, Sophie Jaillard, more

American Journal of Obstetrics and Gynecology > 2004 > 191 > 6 Supplement > S132

article

Does antenatal glucocorticoid improve pulmonary circulatory adaptation at birth?

Philippe Deruelle, Veronique Debarge, Eric Magnenant, Sophie Jaillard, more

American Journal of Obstetrics and Gynecology > 2004 > 191 > 6 Supplement > S145

article

Perinatal glucose tolerance after intrauterine growth restriction in the late-gestation ovine fetus

Philippe Deruelle, Iva Gueorguieva, Berengere Sicot De Jenlis, Sophie Jaillard, more

American Journal of Obstetrics and Gynecology > 2004 > 191 > 6 Supplement > S132

article

Effects of antenatal glucocorticoids on pulmonary vascular reactivity in the ovine fetus

Philippe Deruelle, Veronique Houfflin-Debarge, Eric Magnenant, Sophie Jaillard, more

American Journal of Obstetrics and Gynecology > 2003 > 189 > 1 > 208-215

Objectives: Although mechanisms of glucocorticoids-induced parenchymal lung maturation have been largely studied, little is known about the pulmonary vascular effects of antenatal glucocorticoids (GCs). We therefore hypothesized that antenatal GCs may alter the hemodynamic response to vasodilatory agents in the fetal lung. Study Design: We tested the hemodynamic response to acetylcholine, increased...

article

Effects of inhaled nitric oxide on gas exchange and acute lung injury in premature lambs with moderate hyaline membrane disease

Sophie Jaillard, Yvon Riou, Serge Klosowski, Fabrice Cneude, more

European Journal of Cardio-Thoracic Surgery > 2000 > 18 > 3 > 334-341

Objective: The purpose of this study was to examine whether inhaled nitric oxide (iNO) may change lung injury in moderate hyaline membrane disease (HMD). Methods: Fifteen moderately premature lambs (128 days gestation, term=147 days) were randomly assigned to treatment with 20 ppm inhaled NO (n=7) from the onset of ventilation or control (n=8). Except for inhaled NO, treatments were intentionally...

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Keywords

LUNG (2)
25 (1)
CYSTIC FIBROSIS (1)
CYTOCHROME P450 (1)
EXTRAVASCULAR LUNG WATER CONTENT (1)
GENE EXPRESSION (1)
INFLAMMATION (1)
LUNG LEAK INDEX (1)
NON-SMALL CELL LUNG CANCER (1)
NUCLEAR RECEPTORS (1)
PULMONARY VASCULAR PERMEABILITY (1)
RESPIRATORY DISTRESS SYNDROME (1)
ST3GAL4 (1)
TAQMAN LOW DENSITY ARRAYS (TLDA) (1)
TAQMAN LOW-DENSITY ARRAY (1)
TERMINAL GLYCOSYLATION (1)
TRANSCRIPTIONAL REGULATION (1)
TRANSPORTERS (1)
XENOBIOTIC-METABOLIZING ENZYMES (XME) (1)
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Search results for: Sophie Jaillard

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