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In the last few years, our research group has focused on the design and development of plasmid DNA (pDNA) based systems as devices to be used therapeutically in the biomedical field. Biocompatible macro and micro plasmid DNA gels were prepared by a cross-linking reaction. For the first time, the pDNA gels have been investigated with respect to their swelling in aqueous solution containing different...
Plasmid DNA (pDNA) was efficiently encapsulated into biocompatible microgels by an inverse microemulsion polymerization method using ethylene glycol diglycidyl ether (EGDE) as cross-linker. Plasmid DNA and an anticancer drug, doxorubicin (DOX), could both be loaded with high encapsulation efficiency and released from pDNA microgels; quite relevant is also the less toxic effect of the incorporated...
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