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The eukaryotic helicase is an 11‐subunit machine containing an Mcm2‐7 motor ring that encircles DNA, Cdc45 and the GINS tetramer, referred to as CMG (Cdc45, Mcm2‐7, GINS). CMG is “built” on DNA at origins in two steps. First, two Mcm2‐7 rings are assembled around duplex DNA at origins in G1 phase, forming the Mcm2‐7 “double hexamer.” In a second step, in S phase Cdc45 and GINS are assembled onto...
Penicillins and cephalosporins bearing an S-aminosulfenimine side chain at the 6- and 7-positions, respectively, are prototypic examples of novel classes of β-lactamase-dependent prodrugs wherein enzyme-catalyzed cleavage of the β-lactam ring triggers the rapid expulsion of the S-amino moiety. The cephalosporin structure behaves as a dual-release prodrug as here release of both the S-amino moiety...
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