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The frog skin peptide temporin L (TL, 13-residues long) has a wide and potent spectrum of antimicrobial activity, but it is also toxic on mammalian cells at its microbicidal concentrations. Previous studies have indicated that its analogue [Pro 3 ]TL has a slightly reduced hemolytic activity and a stable helical conformation along residues 6–13. Here, to expand our knowledge on the relationship...
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