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In the present study, we have created a stable HEK293 cell line expressing the human homomeric α1 glycine receptor (GlyR) and characterised its functional pharmacology in a conventional patch-clamp assay and in the FLIPR ( R) Membrane Potential (FMP) assay, a fluorescence-based high throughput screening assay. In the patch-clamp assay, the α1 GlyR exhibited the properties expected from a strychnine-sensitive...
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