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The presence of functional endothelin ET B receptors was investigated in rat isolated mesenteric resistance arteries. Neither endothelin-3 (0.1-100 nM) nor the endothelin ET B selective agonists sarafotoxin S6c and BQ 3020 (both 1-100 nM) induced any measurable hyperpolarization or relaxation in stimulated (α 1 -adrenoceptor agonist; phenylephrine) or unstimulated arteries...
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