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Tetrahydrocurcumin (THC) is known to be the major metabolite of curcumin. The present study aimed to investigate the efficacy of THC and curcumin against hepatic fibrogenesis and the underlying responsible molecular mechanisms. Hepatic fibrogenesis was induced by intraperitoneal injection of CCl4 twice per week for 8weeks. Daily oral administration of THC at 10mg/kg and 50mg/kg attenuated liver fibrogenesis...
Pracparatum mungo is a traditional and functional food in Traditional Chinese Medicine, especially for treating a variety of liver disorders. In this study, we first report the in vivo hepatoprotective effect of P. mungo extract (PME) on carbon tetrachloride (CCl 4 )-induced acute hepatotoxicity in rats. Pre-treatment with PME for 56days significantly reduced the impact of CCl 4 toxicity...
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