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Recent researches revealed that phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) plays an important role in the development of drug resistance, reducing the anti-tumour activity of cytotoxic drugs, such as docetaxel (DTX). The aim of this reported work has been to evaluate DTX and the PI3K/Akt inhibitor perifosine co-loaded Fol/R7 (folate/R7) nanoparticles (NPs) for enhancing anti-cancer activity...
A self-microemulsifying drug delivery system (SMEDDS) of Brucea javanica oil (BJO) was developed and evaluated for its oral absorption and bioavailability. Based on a solubility study and pseudo-ternary phase diagrams, the self-microemulsifying formulation composed of BJO, Cremorphor RH40, Plurol Oleique CC 497 and glycerol (30/42/20/8, % w/w) was prepared and characterised, including particle size,...
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