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Tumors are 3D, composed of cellular agglomerations and blood vessels. Therapies involving nanoparticles utilize specific accumulations due to the leaky vascular structures. However, systemically injected nanoparticles are mostly uptaken by cells located on the surfaces of cancer tissues, lacking deep penetration into the core cancer regions. Herein, an unprecedented strategy, described as injecting...
In article number 1707557, Jinwoo Lee, Won Jong Kim, and co‐workers demonstrate nanoparticle‐loaded nanoparticles comprising large‐pored silica nanoparticles and gold nanoparticles operated by functional DNA. Depending on the pH gradient in the cancer microenvironment, an elaborately programmed DNA transition induces dynamic behavior of the nanoparticle‐loaded nanoparticle with three stages: preferential...
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