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In this study a mesoporous silica nanoparticle (MSNP) based platform is developed for high‐dose loading of a range of activated platinum (Pt) chemo agents that can be attached to the porous interior through the use of electrostatic and coordination chemistry under weak‐basic pH conditions. In addition to the design feature for improving drug delivery, the MSNP can also be encapsulated in a coated...
Effective delivery of activated oxaliplatin to pancreatic cancer achieved by a tailored silicasome nanocarrier is reported by Andre E. Nel, Huan Meng, and co‐workers in article number 2005993. This provides a strong immunogenic cell death stimulus that turns the “cold” immunological status into “hot” at tumor site, enabling superior chemo‐immunotherapy synergy with anti‐PD‐1.
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