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The human NPY Y 1 receptor undergoes fast agonist-induced internalization via clathrin-coated pits then recycles back to the cell membrane. In an attempt to identify the molecular determinants involved in this process, we studied several C-terminal truncation mutants tagged with EFGP. In the absence of agonist, Y 1 receptors lacking the last 32 C-terminal amino acids (Y 1 Δ32)...
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