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The possible role of glutamate, aspartate, sulfur-containing excitatory amino acids and γ-glutamyl peptides as major transmitters in the rat optic nerve was evaluated. Four days following optic nerve lesion the K + -evoked Ca + -dependent glutamate release was reduced to 31 ± 16% (±S.D., n = 9) comparing release from slices of the denervated (contralateral to the lesion) and non-denervated...
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