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Distinguish good from evil by selective endosomal escape. The nuanced endo/lysosomal activity of cathepsin B across cell types can act as a stimulus for cell‐specific endosomal escape of proteins before degradation. In their Research Article (e202317817), Kazunori Kataoka, Horacio Cabral, et al. report nanocarriers leveraging on this differentiated cathepsin B activity to achieve cancer cell‐specific...
The differential enzymatic activity in the endo/lysosomes of particular cells could trigger targeted endosomal escape functions, enabling selective intracellular protein delivery. However, this strategy may be jeopardized due to protein degradation during endosomal trafficking. Herein, using custom made fluorescent probes to assess the endosomal activity of cathepsin B (CTSB) and protein degradation,...