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Barasertib (AZD1152) is a highly potent and selective Aurora B kinase inhibitor. The safety, efficacy and pharmacokinetic (PK) profile of barasertib were investigated in Japanese patients with advanced acute myeloid leukemia. Barasertib (50–1200mg) was administered as a continuous 7-day intravenous infusion every 21 days. No dose-limiting toxicities were reported and barasertib 1200mg was chosen for...
We here present an extremely rare case of granular lymphocytic leukemia derived from γδ T-cell (γδ T-GLL). The blood picture at diagnosis was as follows; white cell count 25.7x10 9 /l containing 94% atypical lymphocytes with cytoplasmic granules, hemoglobin 11.8 g/dl and platelet count 124x10 9 /l. The atypical lymphocytes were positive for CD2, CD3, CD5, CD7, CD56 and TCR γδ, but...
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