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Ca 2+ release through ryanodine receptors, located in the membrane of the junctional sarcoplasmic reticulum (SR), initiates contraction of cardiac muscle. Ca 2+ influx through plasma membrane L-type Ca 2+ channels is thought to be an important trigger for opening ryanodine receptors (««Ca 2+ -induced Ca 2+ -release»»). Optimal transmission of the transmembrane...
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