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Background
Due to high IgE recognition frequency and high allergenic activity, Der p 5 and Der p 21 are clinically important house dust mite (HDM) allergens. The objective of this study was to characterize the immunodominant IgE epitopes of Der p 5 and Der p 21 responsible for their high allergenic activity.
Methods
A panel of 12 overlapping peptides spanning the Der p 5 and Der p 21 sequence were...
Background
Proton pump inhibitors (PPIs) have been known to induce type I hypersensitivity reactions. However, severe delayed‐type hypersensitivity reactions (DHR) induced by PPI, such as Stevens‐Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), or drug rash with eosinophilia and systemic symptoms (DRESS), are rarely reported. We conducted a study of a large series of PPI‐related DHR, followed...
Introduction
There is little information on recent trends in the economic burden of asthma. Our objective was to estimate the excess costs of asthma and their trend in British Columbia, Canada, from 2002 to 2011.
Methods
A retrospective cohort of individuals aged 5–55 years was constructed from the provincial administrative health databases, consisting of patients with physician‐diagnosed asthma...
BackgroundAsthma control is increasingly used as an outcome measure in asthma trials. Economic evaluations of asthma interventions require converting the impact of interventions on control to impact on resource use. The purpose of this study was to estimate the savings in direct costs by achieving asthma symptom control as defined in the Global Initiative for Asthma (GINA) 2014 management strategy...
BackgroundThe epidemiologic profiles of chronic urticaria (CU) vary considerably among regions, and few such data are available from China.
MethodsWe performed a multicenter open questionnaire investigation about the clinical and laboratory features of CU, defined as recurrent wheals with/without angioedema lasting for ≥6 weeks, among 3027 patients.
ResultsFemale preponderance was observed (female/male...
BackgroundMore than 90% of house dust mite‐allergic patients are sensitized to the major Dermatophagoides pteronyssinus allergen, Der p 2. The aim of this study was to develop and characterize an allergy vaccine based on carrier‐bound Der p 2 peptides, which should allow reducing IgE‐ and T‐cell‐mediated side‐effects during specific immunotherapy (SIT).
MethodsFive Der p 2 peptides (P1–P5) were synthesized...
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