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The Wnt/β-catenin signaling pathway plays important roles in animal development and cancer. Pygopus (Pygo) and Legless (Lgs) are recently discovered core components of the Wnt/β-catenin transcription machinery complex, and are crucially involved in the regulation of the transcription of the Arm/β-catenin and T cell factors (TCF). Lgs/Bcl9 functions as an adaptor between Pygo and Arm/β-catenin. Here,...
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