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The ribonucleoprotein enzyme telomerase maintains telomeres and is essential for cellular immortality in most cancers. Insight into the telomerase mechanism can be gained from short telomere syndromes, in which mutation of telomerase components manifests in telomere dysfunction. We carried out detailed kinetic analyses and molecular modelling of a disease-associated mutant in the C-terminal extension...
The C‐terminal Src kinase (Csk) and Csk‐homologous kinase (CHK) are endogenous inhibitors of the proto‐oncogenic Src family of protein tyrosine kinases (SFKs). Phosphotyrosyl peptide binding to their Src‐homology 2 (SH2) domains activates Csk and CHK, enhancing their ability to suppress SFK signalling; however, the detailed mechanistic basis of this activation event is unclear. The CHK SH2 was expressed...
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