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Working with students at the undergraduate, graduate and postdoctoral levels has brought me great joy and satisfaction. Each student is a unique human being, so each provides an important opportunity for learning, creativity and accomplishment in research and scholarship. In this reflection, several examples of this scientific process are discussed in the context of solving scientific problems which...
The blood-brain barrier prevents the entry of many potentially therapeutic peptide drugs to the brain. Glycosylation has shown potential as a methodology for improving delivery to the CNS. Previous studies have shown improved bioavailability and improved centrally mediated analgesia of glycosylated opioids. In this study we investigate the effect of glycosylation on the cyclic opioid peptide [d-Cys...
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