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Objective: To measure tissue pharmacokinetics of trovafloxacin (CP 99,219) in normal and infected animals by both direct tissue radioactivity measurements and positron emission tomography (PET). Methods: Concentrations of [ 18 F]trovafloxacin were measured in normal and infected rats (n = 6/group), at 10, 30, 60, and 120 min after injection, by radioactivity measurements. In normal rabbits...
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