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Tissue Engineering
In article number 2304153, Sungsu Park, Su Ryon Shin, and co‐workers introduce a novel bioengineering method to develop muscle connective tissue‐layered myofibers using a human‐induced pluripotent stem cell‐derived paraxial mesoderm. The development of stem cell fate‐controlling biomaterials via control of the reciprocal activities of transforming growth factor‐beta 1 and its inhibitor...
Skeletal muscle connective tissue (MCT) surrounds myofiber bundles to provide structural support, produce force transduction from tendons, and regulate satellite cell differentiation during muscle regeneration. Engineered muscle tissue composed of myofibers layered within MCT has not yet been developed. Herein, a bioengineering strategy to create MCT‐layered myofibers through the development of stem...
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