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Proteasomes are therapeutic targets for various cancers and autoimmune diseases. Constitutively expressed proteasomes have three active sites, β1c, β2c, and β5c. Lymphoid tissues also express the immunoproteasome subunits β1i, β2i, and β5i. Rapid and simultaneous measurement of the activity of these catalytic subunits would assist in the discovery of new inhibitors, improve analysis of proteasome...
Gebunden, aber nicht unzertrennlich: Der im Titel beschriebene Linker ist unter verschiedenen biologischen Bedingungen beständig, kann aber mit Hydrazin chemoselektiv gespalten werden (siehe Schema). Der Linker wurde zur aktivitätsbasierten Anreicherung und Identifizierung aktiver Proteasom‐Untereinheiten aus Zellextrakten eingesetzt.
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