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Abstract. The A2A-adenosine receptor has an extended carboxy terminus (~120 amino acids), the role of which is poorly defined. In human endothelial cells and in HEK293 cells, the A2A-receptor controls at least two independent signalling pathways, i.e. increased cyclic adenosine 3,5-monophosphate (cAMP) formation via its cognate G protein Gs and increased phosphorylation of mitogen-activated protein...
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