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This review focuses on the biological relevance of receptors of the calcitonin (CT) family of peptides and respective ligands assessed in vivo through removal or overexpression of receptor components in mice. Receptors of the CT peptide family consist of the structurally related seven transmembrane-domain G protein-coupled CT- (CTR) or CT receptor-like (CLR) receptors and associated distinct receptor-activity-modifying...
Adrenomedullin (ADM) is a hypotensive peptide with structural homology, including a ring structure linked by a disulfide bridge, to calcitonin gene-related peptide (CGRP), calcitonin and amylin. ADM is predominantly synthesized in the adrenal medulla, but immunoreactive ADM has also been detected in the human brain. Here we have characterized ADM binding sites in cultured rat astrocytes using human...
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