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A central goal of neuroscience is to understand how the responses of populations of neurons and the connectivity patterns between groups of neurons allow brains to perform computations. The Neural Engineering Framework (NEF) is a promising approach to designing neural models that perform a wide range of computations. Emerging principles of efficient coding and divisive normalization from neuroscience...
There is growing evidence that aspects of perception and behavior can be described as Bayesian inference. Consequently, the ability to perform Bayes-optimal estimation of a stimulus encoded in a neural population can serve as a principle for evaluating the optimality of a neural representation. Here we show that the center-of-mass (COM) decoder can produce estimates of encoded stimulus parameters...
Bullwhip and mini-bullwhip cells are unconventional types of retinal neurons that utilize the neuropeptides glucagon, glucagon-like peptide 1 (GLP1) and substance P. These cells have been implicated in regulating the proliferation of neural progenitors in the circumferential marginal zone (CMZ) of the chicken retina. The purpose of this study was to investigate the roles of the bullwhip cells in regulating...
Cisplatin is used in the treatment of ovarian and testicular cancer. Twenty percent of patients cannot be optimally treated because of sensory neurotoxicity. Human and animal studies demonstrate that the dorsal root ganglion neuron is the primary target of drug injury. We have previously demonstrated that cisplatin causes neuronal apoptosis in vitro. We now report a reproducible animal model of cell...
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