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NF-ATc and NF-ATp, the most prominent NF-AT transcription factors in activated T cells, control the induction of lymphokine genes during T cell activation, in particular the induction of IL-2 and IL-4 genes. While NF-ATp is constitutively expressed, NF-ATc is known to be inducibly expressed. However, we show here that NF-ATc occurs in three isoforms in lymphoid cells, in the inducible isoform NF-ATc/A...
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