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In addition to their well known anti-viral functions, Type I IFN’s and their associated genes have been shown to enhance certain bacterial infections. These observations have led to the concept that the positive vs negative effects of Type I IFN in infection may be context dependent and in the case of bacterial diseases such as tuberculosis and listeriosis raise the possibility of targeting Type IFN...
SEPS1 (also called selenoprotein S, SelS) plays an important role in the production of inflammatory cytokines and its expression is activated by endoplasmic reticulum (ER) stress. In this report, we have identified two binding sites for the nuclear factor kappa B in the human SEPS1 promoter. SEPS1 gene expression, protein levels and promoter activity were all increased 2–3-fold by TNF-α and IL-1β...
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