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Recent studies from other laboratories reported that during methanol intoxication lipid peroxidation and protein oxidation in liver occurred. Further, they detected free radicals-PBN adducts in bile and urine of methanol poisoned rats. In this work, we report the presence in liver microsomes and nuclei of NADPH dependent processes of hydroxymethyl (HMet) radical formation. The detection of HMet radicals...
Depression of liver microsomal glucose-6-phosphatase activity is relevant feature of CCl 4 poisoning. In vitro studies from several laboratories led to the hypothesis that a CCl 4 promoted lipid peroxidation process is responsible for that effect. In vivo studies from our laboratory with potent antioxidants in dosage regimes inhibiting lipid peroxidation, however, were in contrast...
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