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Intervertebral discs demonstrate degenerative changes relatively early in life. Disc degeneration, in turn, is associated with back pain and disc herniation, both of which cause considerable clinical problems in the western world. Cell senescence has been linked to degenerative diseases of other connective tissues such as osteoarthritis. Thus we investigated the degree of cell senescence in different...
Inflammation and irritation of the nerve roots has been indicated as an important factor in the pain associated with symptomatic disc herniations. Tumour necrosis factor α (TNFα) is now believed to be involved in this pathway. TNFα causes connective tissue cells in culture to synthesise a glycoprotein, TNFα-stimulated gene-6 (TSG-6). TSG-6 is found in inflammatory diseases of related connective tissues,...
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