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Opioid and α2‐adrenoceptor agonists are potent analgesic drugs and their analgesic effects can synergize when co‐administered. These supra‐additive interactions are potentially beneficial clinically; by increasing efficacy and/or reducing the total drug required to produce sufficient pain relief, undesired side effects can be minimized. However, combination therapies of opioids and α2‐adrenoceptor...
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