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Objectives and hypothesis
Vocal dysfunction, including hypophonia, in Parkinson disease (PD) manifests in the prodromal period and significantly impacts an individual's quality of life. Data from human studies suggest that pathology leading to vocal deficits may be structurally related to the larynx and its function. The Pink1−/− rat is a translational model used to study pathogenesis in the context...
Objectives/Hypothesis
Voice disorders in Parkinson's disease (PD) are early‐onset, manifest in the preclinical stages of the disease, and negatively impact quality of life. The complete loss of function in the PTEN‐induced kinase 1 gene (Pink1) causes a genetic form of early‐onset, autosomal recessive PD. Modeled after the human inherited mutation, the Pink1−/− rat demonstrates significant cranial...
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