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MEN 10930 (Nα{N-[(1H)indol-3-yl-carbonyl]1-amino-cyclohexane-1-carbonyl}L-3-(2-naphth yl)alanine N-(benzyl) N methyl amide) interacts with high affinity with NK 1 tachykinin receptor expressed in human IM9 (K i = 1.0 +/- 0.17 nM) and U373MG (K i = 2.8 +/- 0.5 nM) cells and guinea pig lung membranes (K i = 5.9 +/- 0.8 nM). MEN 10930 shows no affinity for NK i ...
Neurochemical and functional studies were performed to investigate the role of substance P (SP) during trinitrobenzene sulfonic acid (TNB)-induced colitis. Time course studies showed that tissutal SP-like immunoreactivity levels decreased in acute or chronic phases of the experimental colitis. The affinity of SP was not significantly reduced up to 1 week after TNB-induced colitis but a decreased density...
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