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Pancreatic ductal adenocarcinoma (PDAC) is on of the most lethal malignant tumors with relatively poor prognosis, characterized with insufficient drug penetration, low immune response and obvious drug resistances. The therapeutic inefficiency is multifactorially related to its specific tumor microenvironment (TME), which is representatively featured as rich stroma and immunosuppression. In this work,...
Pancreatic Cancer Treatment
In article number 2107712, Tao Sun, Chen Jiang, and co‐workers develop a versatile drug delivery system that can co‐encapsulate two hypoxia‐responsive prodrugs modified from gemcitabine and a STAT3 inhibitor. The system can respond to the gradient pH variation in the tumor microenvironment to realize higher penetration by reversing its surficial charges, with the aim of...
Current therapeutic strategies for Alzheimer's disease (AD) treatments mainly focus on β‐amyloid (Aβ) targeting. However, such therapeutic strategies have limited clinical outcomes due to the chronic and irreversible impairment of the nervous system in the late stage of AD. Recently, inflammatory responses, manifested in oxidative stress and glial cell activation, have been reported as hallmarks in...
Molybdenum disulfide (MoS2) has emerged as a prominent nanomaterial in photoelectrocatalytic water splitting due to its appropriate energy band and low production cost. However, its low-density active site and poor-efficiency electron transfer have essentially limited the photoelectrocatalytic properties. In this present study, we have proposed a simple yet novel ammoniated molybdenum disulfide with...
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