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Background
Diabetes mellitus‐induced erectile dysfunction (DMED) is one of the complications of diabetes and has a poor response to phosphodiesterase type 5 inhibitor, the first‐line treatment for ED. Saxagliptin (Sax), a dipeptidyl peptidase‐4 inhibitor (DPP‐4i), has been officially used in the treatment of type 2 diabetes. Stromal cell‐derived factor‐1 (SDF‐1) is one of the important substrates...
Backgrounds
Erectile dysfunction (ED) is a common andrological disorder that tends to afflict diabetic patients, among others. Pharmacological therapy of diabetes mellitus‐induced ED (DMED) is ineffective, as it is linked with smooth muscle cell loss in the corpus cavernosum. Ferroptosis is a recently identified kind of cell death evoked by lipid peroxidation, and it is connected with a number of...
Background
The management of diabetes mellitus‐induced erectile dysfunction (DMED) is progressively becoming tricky due to the surge in the number of patients and the poor efficiency of phosphodiesterase type 5 inhibitors in DMED. Paeonol (Pae), as a traditional Chinese medicine, has been more and more widely used in the treatment of diabetic complications. However, whether Pae could be a potential...
Background
Neurogenic erectile dysfunction (NED) caused by cavernous nerve (CN) injury is a typical complication after pelvic surgery, which lacks efficient treatments. Acetyl‐L‐carnitine (ALCAR) has been proven to promote nerve repair.
Objectives
To investigate the effect and potential mechanism of ALCAR in the treatment of NED.
Materials and methods
Thirty‐two rats were randomly divided into...
Background
The population with diabetes mellitus‐induced erectile dysfunction is increasing rapidly, but current drugs are not effective in treating erectile dysfunction. Studies of the traditional Chinese medicine extract berberine on diabetes and its complications provide us with new ideas.
Objectives
To evaluate the therapeutic effect and potential mechanism of berberine on the erectile function...
Background
The coronavirus disease 2019 (COVID‐19) has been spreading all over the world since December 2019. However, medical information regarding the urogenital involvement in recovered COVID‐19 patients is limited or unknown.
Objectives
To comprehensively evaluate urogenital involvement in recovered COVID‐19 patients.
Materials and methods
Men aged between 20 years and 50 years who were diagnosed...
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