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The boundary shift integral (BSI) is a widely used method for measuring atrophy rate, dynamic changes of the gray-matter and cerebrospinal fluid boundaries in magnetic resonance images. BSI is based on intensity differences on this boundary region. This work extends the method in two respects: 1) Instead of using only intensity information on the boundary region, a probabilistic approach is proposed...
Hippocampal volumetric measures may be useful for Alzheimer’s disease (AD) diagnosis and disease tracking; however, manual segmentation of the hippocampus is labour-intensive. Therefore, automated techniques are necessary for large studies and to make hippocampal measures feasible for clinical use. As large studies and clinical centres are moving from using 1.5 Tesla (T) scanners to higher field strengths...
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