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The blood-brain barrier (BBB) has been shown capable being opened noninvasively through the combined application of focused ultrasound (FUS) and microbubbles. In order to better identify the underlying mechanism responsible for BBB opening as well as associated safety, the in vivo noninvasive and transcranial cavitation detection associated with FUS-induced BBB opening was studied. A cylindrically...
Focused ultrasound (FUS) in combination with microbubbles has been shown capable of delivering large molecules to the brain parenchyma through opening of the blood-brain barrier (BBB). However, the mechanism behind the opening remains unknown. To investigate the pressure threshold for inertial cavitation of preformed microbubbles during sonication, passive cavitation detection in conjunction with...
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