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Nonobese diabetic recombination activating gene-null perforin-null (NOD-Rag1 null Prf1 null ) mice, which totally lack mature T and B cells and natural killer cell cytotoxic function, survive longer and are easier to breed than NOD-severe combined immunodeficiency (scid) or NOD-scid/β 2 -microglobulin null mice. We have tested the use of NOD-Rag1 null Prf1 ...
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