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Visual impairment in diabetes is a growing public health concern. Apart from the well‐defined diabetic retinopathy, disturbed optic nerve function, which is dependent on the myelin sheath, has recently been recognized as an early feature of visual impairment in diabetes. However, the underlying cellular mechanisms remain unclear. Using a streptozotocin‐induced diabetic mouse model, we observed a myelin...
Reactive astrogliosis is a pathological feature of spinal cord injury (SCI). The ubiquitin‐proteasome system plays a crucial role in maintaining protein homeostasis and has been widely studied in neuroscience. Little, however, is known about the underlying function of deubiquitinating enzymes in reactive astrogliosis following SCI. Here, we found that ubiquitin‐specific protease 18 (USP18) was significantly...