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Background
Genetic and environmental factors are important determinants of nasopharyngeal carcinoma (NPC). NPC is associated with Epstein‐Barr virus (EBV) infection. Studies have reported familial aggregation of NPC, but evidence has been mixed for elevated rates of cancers other than NPC.
Methods
The authors reassessed their previous evaluation of familial aggregation of cancer in 348 high‐risk...
Background
Although stratifying individuals with respect to nasopharyngeal carcinoma (NPC) risk with Epstein‐Barr virus–based markers is possible, the performance of diagnostic methods for detecting lesions among screen‐positive individuals is poorly understood.
Methods
The authors prospectively evaluated 882 participants aged 30 to 70 years who were enrolled between October 2014 and November 2018...
BACKGROUND
Human papillomavirus 16 (HPV16) E6 antibodies may be an early marker of the diagnosis and recurrence of human papillomavirus–driven oropharyngeal cancer (HPV‐OPC).
METHODS
This study identified 161 incident oropharyngeal cancer (OPC) cases diagnosed at the University of Pittsburgh (2003‐2013) with pretreatment serum. One hundred twelve had preexisting clinical HPV testing with p16 immunohistochemistry...
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