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A mitochondrial‐targeting photosensitizer with aggregation‐induced emission characteristics can serve as an effective radiosensitizer. In article number 1606167, Xiaolin Li, Dan Ding, Ben Zhong Tang, and co‐workers demonstrate that the radiosensitivity of cancer cells to ionizing radiation can be synergistically enhanced by an increased singlet oxygen environment in the mitochondria of cancer cells...
The first mitochondrion‐anchoring photosensitizer that specifically generates singlet oxygen (1O2) in mitochondria under white light irradiation that can serve as a highly effective radiosensitizer is reported here, significantly sensitizing cancer cells to ionizing radiation. An aggregation‐induced emission luminogen (AIEgen), namely DPA‐SCP, is rationally designed with α‐cyanostilbene as a simple...
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