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Background As the main downstream effecter of tumor suppressor p53, p21Waf1/Cip1 functions as a unique link from p53 to cell-cycle arrest and DNA repair. In contrast to p53, p21Waf1/Cip1 has general rare mutations. The natural genetic variants of p21Waf1/Cip1 have thus emerged for study to enhance understanding of interindividual differences in cancer risk. Two polymorphisms in the p21Waf1/Cip1...
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