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Zn2+ is an essential component of metalloproteinases, and is required for their activity in cartilage; however, the effect of Zn2+ on nucleus pulposus (NP) cells has not been widely investigated. The aim of this paper was to investigate the effect of intracellular Zn2+ concentration ([Zn2+]i) in hypoxia-induced regulation of metalloproteinases (MMPs) and extracellular matrix (ECM) production in NP...
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