Search results for: Hidenori Ando

Items from 1 to 18 out of 18 results

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Indocyanine green‐labeled dasatinib as a new fluorescent probe for molecular imaging of gastrointestinal stromal tumors

Shota Fujimoto, Naoki Muguruma, Michiyasu Nakao, Hidenori Ando, more

Journal of Gastroenterology and Hepatology > 36 > 5 > 1253 - 1262

Background and Aim It is difficult to differentiate gastrointestinal stromal tumors (GISTs) from other subepithelial lesions under gastrointestinal endoscopy. Because most GISTs express tyrosine kinase receptor c‐KIT, fluorescence‐labeled c‐KIT‐specific tyrosine kinase inhibitors seem to be useful agents for molecular imaging of GIST. We aimed to develop a near‐infrared fluorescent imaging technology...

article

A Cell Assay for Detecting Anti-PEG Immune Response against PEG-Modified Therapeutics

Taro Shimizu, Amr S. Abu Lila, Mizuki Awata, Yukiyo Kubo, more

Pharmaceutical Research > 2018 > 35 > 11 > 1-10

Purpose Immunogenicity of PEGylated proteins and nanomedicines represents a potential impediment against their development and use in clinical settings. The purpose of this study is to develop a method for detecting anti-PEG immunity of PEGylated proteins and/or nanomedicines using flow cytometry. Methods The binding of fluorescence-labeled mPEG-modified liposomes to HIK-G11 cells, PEG-specific...

article

Reactivity of IgM antibodies elicited by PEGylated liposomes or PEGylated lipoplexes against auto and foreign antigens

Hidenori Ando, Amr S. Abu Lila, Munehira Kawanishi, Taro Shimizu, more

Journal of Controlled Release > 2018 > 270 > C > 114-119

Polyethylene glycol (PEG) is an attractive tool for the development of nanoparticle-based cancer therapy since it endows nanoparticles with extended-circulation properties. Nevertheless, recent reports have revealed that intravenous injection of either PEGylated liposomes (SLs) or PEGylated lipoplex (PLpx) could elicit an anti-PEG immunoglobulin (IgM) response in a T cell-independent (TI) manner that...

article

Liposomalization of oxaliplatin induces skin accumulation of it, but negligible skin toxicity

Kentaro Nishida, Misaki Kashiwagi, Shunsuke Shiba, Kiwamu Muroki, more

Toxicology and Applied Pharmacology > 2017 > 337 > C > 76-84

Liposomalization causes alteration of the pharmacokinetics of encapsulated drugs, and allows delivery to tumor tissues through passive targeting via an enhanced permeation and retention (EPR) effect. PEGylated liposomal doxorubicin (Doxil^®, Lipo-DXR), a representative liposomal drug, is well-known to reduce cardiotoxicity and increase the anti-tumor activity of DXR, but to induce the hand-foot syndrome...

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Co-administration of liposomal l-OHP and PEGylated TS shRNA-lipoplex: A novel approach to enhance anti-tumor efficacy and reduce the immunogenic response to RNAi molecules

Eman Alaaeldin, Amr S. Abu Lila, Hidenori Ando, Masakazu Fukushima, more

Journal of Controlled Release > 2017 > 255 > C > 210-217

Many therapeutic strategies have been applied in efforts to conquer the development and/or progression of cancer. The combination of chemotherapy and an RNAi-based approach has proven to be an efficient anticancer therapy. However, the feasibility of such a therapeutic strategy has been substantially restricted either by the failure to achieve the efficient delivery of RNAi molecules to tumor tissue...

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Quantitative determination of polysulfide in albumins, plasma proteins and biological fluid samples using a novel combined assays approach

Mayumi Ikeda, Yu Ishima, Akitomo Shibata, Victor T.G. Chuang, more

Analytica Chimica Acta > 2017 > 969 > C > 18-25

Hydrogen sulfide (H₂S) signaling involves polysulfide (RSS_nSR′) formation on various proteins. However, the current lack of sensitive polysulfide detection assays poses methodological challenges for understanding sulfane sulfur homeostasis and signaling. We developed a novel combined assay by modifying Sulfide Antioxidant Buffer (SAOB) to produce an “Elimination Method of Sulfide from Polysulfide”...

article

Ganglioside inserted into PEGylated liposome attenuates anti-PEG immunity

Yu Mima, Amr S. Abu Lila, Taro Shimizu, Masami Ukawa, more

Journal of Controlled Release > 2017 > 250 > C > 20-26

Despite the clinical introduction of a vast number of polyethylene glycol (PEG)-conjugated therapeutics, conjugated PEG is also known for an unfortunate inclination toward immunogenicity. Immunogenicity of PEG, manifested by the robust production of anti-PEG IgM, is known to compromise the therapeutic efficacy and/or reduce the tolerance of PEGylated therapeutics. In the present study, we inserted...

article

One-step encapsulation of siRNA between lipid-layers of multi-layer polycation liposomes by lipoplex freeze-thawing

Hiroyuki Koide, Ayaka Okamoto, Hiroki Tsuchida, Hidenori Ando, more

Journal of Controlled Release > 2016 > 228 > C > 1-8

Small interfering RNA (siRNA) has the potential to be a candidate as a cure for intractable diseases. However, an appropriate vector is required for siRNA delivery because of the low transfection efficiency of siRNA without a vector and its easy degradation in vivo. Here, we report a simple, only one step, and efficient method for siRNA encapsulation into a lipidic nanocarrier by freeze-thawing: siRNA...

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Intra-tumor distribution of PEGylated liposome upon repeated injection: No possession by prior dose

Hiroyuki Nakamura, Amr S. Abu Lila, Miho Nishio, Masao Tanaka, more

Journal of Controlled Release > 2015 > 220 > PA > 406-413

Liposomes have proven to be a viable means for the delivery of chemotherapeutic agents to solid tumors. However, significant variability has been detected in their intra-tumor accumulation and distribution, resulting in compromised therapeutic outcomes. We recently examined the intra-tumor accumulation and distribution of weekly sequentially administered oxaliplatin (l-OHP)-containing PEGylated liposomes...

article

Advanced therapeutic approach for the treatment of malignant pleural mesothelioma via the intrapleural administration of liposomal pemetrexed

Hidenori Ando, Sakiko Kobayashi, Amr S. Abu Lila, Noha Essam Eldin, more

Journal of Controlled Release > 2015 > 220 > PA > 29-36

Malignant pleural mesothelioma (MPM) is an aggressive cancer that proliferates in the pleural cavity. Pemetrexed (PMX) in combination with cisplatin is currently the approved standard care for MPM, but a dismal response rate persists. Recently, we prepared various liposomal PMX formulations using different lipid compositions and evaluated their in vitro cytotoxicity against human mesothelioma cells...

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Anti-PEG IgM and complement system are required for the association of second doses of PEGylated liposomes with splenic marginal zone B cells

Taro Shimizu, Yu Mima, Yosuke Hashimoto, Masami Ukawa, more

Immunobiology > 2015 > 220 > 10 > 1151-1160

The accelerated blood clearance (ABC) phenomenon makes it crucial to use PEGylated liposomes and micelles to deliver drugs. The ABC phenomenon is an immune response against an initial dose of PEGylated liposome, which causes subsequent doses to be rapidly cleared by macrophages in the liver. We recently found that in the early phase of the ABC phenomenon, subsequent doses of PEGylated liposomes were...

article

Susceptibility of PTEN-positive metastatic tumors to small interfering RNA targeting the mammalian target of rapamycin

Hiroyuki Koide, Tomohiro Asai, Hiroki Kato, Norihito Yonenaga, more

Nanomedicine: Nanotechnology, Biology and Medicine > 2015 > 11 > 1 > 185-194

PTEN-positive tumors are not susceptible to the treatment with rapamycin, an inhibitor of the mammalian target of rapamycin (mTOR). Here, we determined the susceptibility of PTEN-positive cells to small interfering RNA for mTOR (si-mTOR) by using a novel liposomal delivery system. We prepared dicetyl phosphate-tetraethylenepentamine-based polycation liposomes (TEPA-PCL) decorated with polyethylene...

article

Antibody-modified lipid nanoparticles for selective delivery of siRNA to tumors expressing membrane-anchored form of HB-EGF

Ayaka Okamoto, Tomohiro Asai, Hiroki Kato, Hidenori Ando, more

Biochemical and Biophysical Research Communications > 2014 > 449 > 4 > 460-465

An Fab’ antibody against heparin-binding epidermal growth factor-like growth factor (HB-EGF) was applied to achieve advanced tumor-targeted delivery of siRNA. Lipid nanoparticles (LNP) encapsulating siRNA (LNP-siRNA) were prepared, pegylated, and surface modified with Fab’ fragments of anti-HB-EGF antibody (αHB-EGF LNP-siRNA). αHB-EGF LNP-siRNA showed high-binding affinity to recombinant human HB-EGF...

article

Advanced cancer therapy by integrative antitumor actions via systemic administration of miR-499

Hidenori Ando, Tomohiro Asai, Hiroyuki Koide, Ayaka Okamoto, more

Journal of Controlled Release > 2014 > 181 > Complete > 32-39

Previously, we developed tetraethylenepentamine-based polycation liposomes (TEPA-PCL) as a vector for the delivery of small RNAs. In the present research, we attempted tumor-targeted delivery of miR-499 via systemic administration and evaluated the potency of this system as a therapeutic strategy to treat cancer. Lipoplexes were formed by mixing cholesterol-grafted miR-499 (miR-499-C) with TEPA-PCL...

article

Variability of factors driving spatial and temporal dispersion in river plume and Chattonella antiqua bloom in the Yatsushiro Sea, Japan

Kazuhiro Aoki, Goh Onitsuka, Manabu Shimizu, Hiroshi Kuroda, more

Marine Pollution Bulletin > 2014 > 81 > 1 > 131-139

The dynamics of river plume in relation to harmful blooms of the raphidophycean flagellate, Chattonella antiqua in summer 2008–2010 in the Yatsushiro Sea, Japan were studied using a hydrodynamic model and monitoring data. In the southern area, the bloom formed in the waters stratified by a halocline caused by the southward expansion of riverine water from the Kuma River after the bloom initially forming...

article

Polycation liposomes as a vector for potential intracellular delivery of microRNA

Hidenori Ando, Ayaka Okamoto, Masafumi Yokota, Tomohiro Asai, more

The Journal of Gene Medicine > 15 > 10 > 375 - 383

BackgroundWe previously developed a microRNA (miRNA) delivery system by using dicetyl phosphate‐tetraethylenepentamine‐based polycation liposomes (TEPA‐PCL), applied it to miR‐92a delivery, and demonstrated its gene‐silencing potential and effective anti‐angiogenic effects. In the present study, we investigated the mechanism of intracellular delivery of cholesterol‐grafted miR‐92a (miR‐92a‐C) into...

article

Development of a miR‐92a delivery system for anti‐angiogenesis‐based cancer therapy

Hidenori Ando, Ayaka Okamoto, Masafumi Yokota, Kosuke Shimizu, more

The Journal of Gene Medicine > 15 > 1 > 20 - 27

BackgroundRNA interference has received much attention as a novel therapeutic strategy. MicroRNA (miRNA) appears to be promising as a novel nucleic‐acid medicine because it is able to suppress a series of protein expression that relates to a specific event such as angiogenesis. In the present study, we used dicetyl phosphate‐tetraethylenepentamine‐based polycation liposomes (TEPA‐PCL) as a delivery...

article

Size-dependent induction of accelerated blood clearance phenomenon by repeated injections of polymeric micelles

Hiroyuki Koide, Tomohiro Asai, Hiroki Kato, Hidenori Ando, more

International Journal of Pharmaceutics > 2012 > 432 > 1-2 > 75-79

An accelerated blood clearance (ABC) phenomenon is induced by repeated injections of poly(ethylene glycol)-modified (PEGylated) liposomes. We previously indicated that the phenomenon was induced by polymeric micelles possessing PEG chains like as liposomes, although, the induction mechanism of the ABC phenomenon is not fully elucidated. In the present study, we investigate whether repeat-injection...

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